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. Author manuscript; available in PMC: 2017 May 23.
Published in final edited form as: Annu Rev Pathol. 2016 Jan 13;11:21–45. doi: 10.1146/annurev-pathol-012615-044116

Figure 5.

Figure 5

Amyloid β (Aβ) plaque pathologies following traumatic brain injury (TBI). Diffuse Aβ plaques can be identified in autopsy and surgical material from approximately 30% of TBI patients during the acute phase post-injury (a, 51-year-old male 24 h following severe TBI). In the following weeks to months, these diffuse plaques resolve, only to reemerge in approximately 30% of survivors 1 year or more after a single, moderate or severe TBI as both neuritic and diffuse Aβ plaques (b, 55-year-old female 47 years after a single, severe TBI). Aβ plaques are also present in a majority of cases of chronic traumatic encephalopathy following exposure to repetitive, mild TBI; these are typically, although not exclusively, diffuse in subtype (c, 60-year-old male, former boxer; d, 59-year-old male, former soccer player). All sections stained using antibody 6F/3D, specific for the N-terminal epitope of Aβ (Dako, Agilent Technologies).