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. 2017 Jan 13;14(3):347–360. doi: 10.1080/15476286.2017.1279786

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Figure 8. — A model depicting role of miR-432 in regulating myogenesis. In proliferating cells (left), suppression of E2F3 mRNA by miR-432 resulted in transcription factor E2F3 decreasing in nucleus to dampen transcription of cell cycle genes and finally caused arrest in G1-phage. In differentiating cells (right), on the one hand, suppression of E2F3 by miR-432 inhibited transcription of MyoG to restrain myogenic differentiation; on the other hand, miR-432 contributed to phosphorylation of its downstream Akt and mTOR being suffocated to block myogenesis by targeted P55PIK.