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. 2017 Feb 8;4(2):160808. doi: 10.1098/rsos.160808

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© 2017 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 4. — Zebrafish β-cell K_ATP channels exhibit similar in pharmacology to mammalian β-cell K_ATP channels. Zebrafish β-cell K_ATP channels show activation by diazoxide (a) but not by pinacidil (b) in excised patches. These channels also show inhibition by both tolbutamide (c) and glibenclamide (d). (e,f) Quantification of activation (e) and inhibition (f) of the K_ATP channels. Asterisk indicates p < 0.05 by the Mann–Whitney test. In (e), the right panel indicates the increase in I_rel produced by each drug, whereas the left panel indicates the fraction of overall maximum current in each condition. These are quantified from recordings of six cells for diazoxide, four cells for pinacidil and glibenclamide, and five cells for tolbutamide.