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. 2017 Jan 24;15(3):1024–1030. doi: 10.3892/mmr.2017.6140

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Copyright: © Qiu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Tyrosine kinase inhibitors induce the apoptosis of TPR-FGFR1-expressing Baf3 cells. (A) Cells were treated with different concentrations of TKI258, ponatinib, or AZD4547 for 24 h. The apoptosis was detected using an Annexin V/PI staining kit. The apoptotic cells were defined as Annexin V⁺/PI⁻ (lower right quadrant) and Annexin V⁺/PI⁺ (upper right quadrant). (B) Quantitative data for the percentages of apoptotic cells were pooled from three independent experiments. *P<0.05, vs. control group. **P<0.01 vs. control group. TPR, translocated promoter region; FGFR1, fibroblast growth factor receptor 1; T, TK1258; P, ponatinib; A, AZD4547.