Figure 5.

Histology image of colon issues obtained from different groups. The colons of animals in group E presented a similar degree of mucosal injury as group B. The degree of colon injury was reduced in group C. Conversely, the injured colon mucosa of animals in groups D and F was relieved significantly compared with the model group, with fewer edema and shallow ulcers. A, control group; B, model group (UC model mice); C, normal dose 5-ASA group (200 mg/kg.day⁻¹ for 7 days); D, high dose 5-ASA group (400 mg/kg.day⁻¹ for 7 days); E, SiO₂ NPs group (100 mg/kg.day⁻¹ for 7 days); F, 5-ASA-SiO₂ NPs group (100 mg/kg day⁻¹ for 7 days).