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. 2017 Jan 19;15(3):1095–1102. doi: 10.3892/mmr.2017.6132

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Copyright: © Shan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Quantification of peripheral blood TFH cell subsets disaggregated by OA clinical grade. The frequency of CD4+CXCR5+, PD-1+CD4+CXCR5+ IL-21+CD4+CXCR5+TFH and ICOS+CD4+CXCR5+ cells for stages II–IV of OA was analyzed. Knee radiographs were evaluated according to the KL classification criteria. Data are expressed as the mean values of individual participants from two separate experiments. (A-D) The frequency of (A) CD4+CXCR5+, (B) PD-1+CD4+CXCR5+, (C) IL-21+CD4+CXCR5+TFH and (D) ICOS+CD4+CXCR5+ cells in stage II–IV of OA. The horizontal lines indicate the median values for each group. OA patients with stage II (n=12), OA patients with stage III (n=15), OA patients with stage IV (n=13), and HC: healthy control group (n=13). OA, osteoarthritis; KL, Kellgren and Lawrence; IL-21, interleukin-21; PD-1, programmed death 1; TFH, follicular helper T.