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. 2017 Jan 5;15(3):1211–1221. doi: 10.3892/mmr.2017.6104

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Copyright: © Guo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Expression of fibrosis-associated genes is decreased following inhibition of miR-21 by miR-21 antagomir in HSFBs. (A) NSFBs and HSFBs were treated with miR-21 antagomir or miR-21 antagomir control for 48 h. Messenger RNA levels of COL1A1, COL1A2 and Fn were determined by reverse transcription-quantitative polymerase chain reaction. (B) Inhibition of collagen synthesis was measured by H3-proline incorporation assay. **P<0.01, comparison indicated by brackets. Experiments were repeated at least three times. Values are presented as the mean ± standard error of the mean. miR, microRNA; HSFBs, hypertrophic scar fibroblasts; NSFBs, normal skin fibroblasts; COL1A1, collagen type I α 1 chain; COL1A2, collagen type I α 2 chain; Fn, fibronectin.