Table III.
Characteristics of ME formulation 1–5 and the skin permeation parameters of phenylethanoid glycoside when delivered by these formulations.
| Characteristics of MEs | |||||
|---|---|---|---|---|---|
| Formulation | Size (nm) | PDI | pH | Viscosity (mPa.s) | Skin permeation parameter Jss (µg/cm−2/h−1) |
| ME1 | 79.21±0.01 | 0.236±0.05 | 7.21±0.01 | 80.51±0.87b (P=0.0076) | 69.57±0.78b (P=0.0094) |
| ME2 | 37.91±0.42 | 0.187±0.03 | 6.98±0.01 | 47.52±0.54b (P=0.0089) | 44.326±0.84b (P=0.0052) |
| ME3 | 67.71±0.13 | 0.243±0.01 | 6.83±0.06 | 60.49±1.34b (P=0.0094) | 79.859±0.12a (P=0.039) |
| ME4 | 45.32±0.04 | 0.321±0.01 | 7.09±0.05 | 43.27±0.21b (P=0.0059) | 58.332±0.39b (P=0.0063) |
| ME5 | 30.56±0.08 | 0.197±0.02 | 6.54±0.03 | 30.43±0.12 (P<0.0001) | 86.795±0.23 (P<0.00010) |
ME, microemulsion; PDI, polydisparity index; Jss, penetration rate.
a
P<0.05
b
P<0.01 vs. permeation rate of ME5.