Figure 1.

Mechanism of action of LCZ696.

Notes: LCZ696 is composed of valsartan (an angiotensin receptor blocker) and sacubitril (a neprilysin inhibitor). Valsartan prevents the binding of angiotensin II to the angiotensin receptor and results in vasodilation, decreased sympathetic tone, and decreased levels of aldosterone. Inhibition of neprilysin by sacubitril prevents the breakdown of both ANP and BNP, resulting in vasodilation, diuresis, natriuresis, and reduced aldosterone levels. Reprinted from JACC: Heart failure; 2(6). Vardeny O, Miller R, Solomon SD. Combined neprilysin and renin-angiotensin system inhibition for the treatment of heart failure. 663–670. Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. With permission from Elsevier.¹³

Abbreviations: ANP, atrial natriuretic peptide; AT₁, angiotensin 1; BNP, B-type natriuretic peptide; CNP, c-type natriuretic peptide; NT, N-terminal.