. Author manuscript; available in PMC: 2017 Aug 1.

Published in final edited form as: Toxicol Appl Pharmacol. 2016 May 3;304:18–29. doi: 10.1016/j.taap.2016.05.001

Table 6.

HNF4α-regulates a multitude of PFOA- and PFOS-altered genes

	HNF4α -regulated Genes
PFOA	ABCB11, ADH1B, APOA4, CIDEC, CPT1A, CYP2B6, CYP7A1, HPS5, MUC4, PCK1, TAT
PFOS	AASS, ABCA6, ABCB10, ABCB11, ABCG5, ADH1B, ATF2, BLVRB, BLZF1, C6orf211, C8orf4, CAPZA2, CCDC82, CCP110, CD46, CEP83, CHST9, CIR1, CPED1, CPT1A, CRYZ, CYP2B6, CYP2C8, CYP3A4, CYP3A5, CYP7A1, DYNC2LI1, EDEM3, EGR1, EMC2, EPM2AIP1, EPPK1, EXO1, F11, F13B, GDF15, GOLGA4, GOLIM4, GRB14, IL6ST, JRKL, KRT7, LARP4, LIN7C, LRRC40, MIS18BP1, MLXIPL, NAMPT, NDUFA5, NEK7, NUAK2, PDCD10, PKM, PMS1, PRPF38B, RAD50, RBM41, RECQL, RMI1, ROCK1, RUVBL2, SCFD1, SCP2, SF3B1, SLC35A3, SLC38A4, SMC2, SRSF11, SSFA2, TAT, TDO2, TMEM123, TMF1, TPX2, TRAIP, TRAPPC8, TRIP11, TTC37, UFM1, UPF3B, USP15, ZBTB11, ZC3H15, ZNF146, ZNF224, ZNF277, ZNF300, ZNF345, ZNF644, ZRANB2

HNF4α -regulated Genes

PFOA

ABCB11, ADH1B, APOA4, CIDEC, CPT1A, CYP2B6, CYP7A1, HPS5, MUC4, PCK1, TAT

PFOS

AASS, ABCA6, ABCB10, ABCB11, ABCG5, ADH1B, ATF2, BLVRB, BLZF1, C6orf211, C8orf4, CAPZA2, CCDC82, CCP110, CD46, CEP83, CHST9, CIR1, CPED1, CPT1A, CRYZ, CYP2B6, CYP2C8, CYP3A4, CYP3A5, CYP7A1, DYNC2LI1, EDEM3, EGR1, EMC2, EPM2AIP1, EPPK1, EXO1, F11, F13B, GDF15, GOLGA4, GOLIM4, GRB14, IL6ST, JRKL, KRT7, LARP4, LIN7C, LRRC40, MIS18BP1, MLXIPL, NAMPT, NDUFA5, NEK7, NUAK2, PDCD10, PKM, PMS1, PRPF38B, RAD50, RBM41, RECQL, RMI1, ROCK1, RUVBL2, SCFD1, SCP2, SF3B1, SLC35A3, SLC38A4, SMC2, SRSF11, SSFA2, TAT, TDO2, TMEM123, TMF1, TPX2, TRAIP, TRAPPC8, TRIP11, TTC37, UFM1, UPF3B, USP15, ZBTB11, ZC3H15, ZNF146, ZNF224, ZNF277, ZNF300, ZNF345, ZNF644, ZRANB2