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. Author manuscript; available in PMC: 2017 Jul 7.
Published in final edited form as: J Phys Chem B. 2016 May 9;120(26):6306–6318. doi: 10.1021/acs.jpcb.6b02768

Figure 1.

Figure 1

The two mechanisms of allostery that we consider in this article. The irreducible assembly unit (a protein dimer in this schematic) interconverts between assembly-inactive and assembly-active conformations, with equilibrium constant KA. In both mechanisms, only assembly-active subunits can combine to form intermediates smaller than a critical nucleus. In the ‘Induced Fit’ mechanism, both assembly-active and assembly-inactive subunits can bind to larger intermediates, whereas in the ‘No Induced Fit’ mechanism, only assembly-active subunits can bind throughout the assembly process.