TABLE 2.

Changes in Metabolic Network Activity Under Different Experimental Conditions

Summary of analysis	PRP1	PRP2	PRP3	PRP4	PRP5
Pattern derivation
Eigenvalue (%)	42.9	43.3	27.8	27.2	48.2
Control 1	0.00 ± 0.41	0.00 ± 0.45	0.00 ± 0.36	0.00 ± 0.33	0.00 ± 0.41
MPTP 1	7.67 ± 1.37	7.91 ± 1.56	3.11 ± 0.25	2.66 ± 0.25	7.78 ± 1.41
MPTP 1 vs. control 1*	0.0037	0.0031	0.00003	0.00008	0.004
Pattern validation
Control 2	0.46 ± 0.36	0.09 ± 0.36	0.22 ± 0.32	0.36 ± 0.28	0.51 ± 0.37
MPTP 2	3.80 ± 0.33	3.88 ± 0.32	3.04 ± 0.22	2.64 ± 0.21	3.64 ± 0.16
MPTP 2 vs. control 2*	0.00001	0.000003	0.00001	0.00003	0.00002
Implant effect
Implant	2.85 ± 0.43	3.10 ± 0.48	2.62 ± 0.39	1.92 ± 0.35	3.21 ± 0.21
Implant vs. MPTP 2 (change %)	−24.6 ± 5.9	−21.6 ± 5.9	−17.6 ± 7.2	−26.8 ± 11.5	−10.9 ± 2.3
Implant vs. MPTP 2†	0.0025	0.011	0.036	0.033	0.0039
Implant vs. control 2*	0.001	0.0003	0.0005	0.004	0.00008
Test–retest effect
Test vs. retest†	0.292	0.342	0.577	0.505	0.351
R2 (Pearson correlation)	0.954	0.952	0.953	0.956	0.926
P	0.000006	0.000007	0.000007	0.000005	0.00003

^*P values: unpaired Student t tests.

^†P values: paired Student t tests.

Eigenvalue for each PRP derivation is given as percentage of total subject × voxel variance (10). Subject scores are presented as mean ± SE for animals used to identify each PRP and to assess effects of implantation.