Table 2.

Meta-analysis results for the five studied polymorphisms and RCC risk

Gene polymorphism	Inherited model	Heterogeneity test		Analysis model	Pooled OR (95% CI)	P-value
		P for Q test	I2 (%)
rs3025039	Allele contrast (T vs C)	0.02	61	REM	1.13 (0.93, 1.37)	0.22
	Homozygous (TT vs CC)	0.24	25	FEM	1.38 (1.11, 1.72)	0.004
	Heterozygous (CT vs CC)	0.24	25	FEM	1.17 (1.00, 1.37)	0.06
	Dominant (TT+CT vs CC)	0.15	39	FEM	1.21 (1.05, 1.39)	0.01
	Recessive (TT vs CT+CC)	0.45	0	FEM	1.28 (1.04, 1.57)	0.02
rs699947	Allele contrast (A vs C)	0.60	0	FEM	1.31 (1.19, 1.45)	<0.00001
	Homozygous (AA vs CC)	0.77	0	FEM	1.69 (1.37, 2.07)	<0.00001
	Heterozygous (CA vs CC)	0.11	47	FEM	1.31 (1.12, 1.52)	0.0006
	Dominant (AA+CA vs CC)	0.19	35	FEM	1.39 (1.21, 1.61)	<0.00001
	Recessive (AA vs CA+CC)	0.78	0	FEM	1.43 (1.19, 1.73)	0.0002
rs10434	Allele contrast (G vs A)	0.60	0	FEM	0.89 (0.80, 1.00)	0.06
	Homozygous (GG vs AA)	0.53	0	FEM	0.75 (0.57, 0.98)	0.03
	Heterozygous (GA vs AA)	0.65	0	FEM	0.82 (0.63, 1.07)	0.15
	Dominant (GG+GA vs AA)	0.57	0	FEM	0.79 (0.61, 1.01)	0.06
	Recessive (GG vs GA+AA)	0.57	0	FEM	0.89 (0.77, 1.04)	0.14
rs1570360	Allele contrast (A vs G)	0.26	25	FEM	1.05 (0.90, 1.22)	0.55
	Homozygous (AA vs GG)	0.47	0	FEM	1.10 (0.81, 1.50)	0.55
	Heterozygous (GA vs GG)	0.40	0	FEM	1.07 (0.83, 1.37)	0.60
	Dominant (AA+GA vs GG)	0.29	19	FEM	1.08 (0.86, 1.36)	0.52
	Recessive (AA vs GA+GG)	0.64	0	FEM	1.04 (0.81, 1.32)	0.78
rs2010963	Allele contrast (C vs G)	0.21	31	FEM	1.04 (0.94, 1.15)	0.49
	Homozygous (CC vs GG)	0.23	28	FEM	1.07 (0.86, 1.32)	0.56
	Heterozygous (CG vs GG)	0.68	0	FEM	1.09 (0.92, 1.28)	0.32
	Dominant (CC+CG vs GG)	0.41	0	FEM	1.09 (0.93, 1.27)	0.29
	Recessive (CC vs CG+GG)	0.44	0	FEM	1.00 (0.84, 1.19)	1.00

Note: P-value of overall effect.

Abbreviations: OR, odds ratio; CI, confidence interval; REM, random effects model; FEM, fixed-effects model; RCC, renal cell carcinoma.