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. 2016 Dec 19;124(4):1330–1338. doi: 10.1213/ANE.0000000000001755

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Copyright © 2016 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Anesthesia Research Society.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 3. — Systematic application of (5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1] octane (PTAC) did not induce a place preference for the chemical-paired chamber. A, Mice with sham treatments spent equal times in the chambers during the preconditioning and testing periods (2-way RM ANOVA, pre versus test: F_1;39 = 0.97, P = .35; drug versus saline: F_1;39 = 0.07, P = .80, interaction: F_1;39 = 0.09, P = .77; n = 10). B, No place preference was detected after the application of PTAC (0.05 mg/kg) to the mice with nerve injuries (2-way RM ANOVA, pre versus test: F_1;35 = 0.02, P = .90; drug versus saline: F_1;35 = 0.01, P = .91, interaction: F_1;35 = 0.18, P = .68; n = 9). C, No difference was detected in the preference times of the sham and injury groups (t test, P > .05). D, Application of PTAC (0.20 mg/kg) did not induce a place preference in mice with sham treatments (2-way RM ANOVA, pre versus test: F_1;39 = 9.54, P < .05; drug versus saline: F_1;39 = 0.02, P = .99, interaction: F_1;39 = 0.37, P = .56; n = 10). E, No place preference was detected after the application of PTAC (0.20 mg/kg) to the mice with nerve injuries (2-way RM ANOVA, pre versus test: F_1;39 = 0.29, P = .60; drug versus saline: F_1;39 = 1.01, P = .34, interaction: F_1;39 = 0.17, P = .69; n = 10). F, Preference time of mice with sham treatments was similar to that of the injury group during the test period (t test, P > .05). ANOVA indicates analysis of variance; RM, repeated measures.