Table 8.
Participant ratings of persisting effects attributed to the session on ratings completed 5 weeks after the low-dose and high-dose psilocybin sessions, and, again, retrospectively for the high-dose session 6 months after the second session+.
| Questionnaire and subscale description | Assessment time-point |
||
|---|---|---|---|
| Low dose (5 weeks) |
High dose (5 weeks) |
High dose 6-month follow-up |
|
| Persisting Effects Questionnaire (% of maximum score) | |||
| Positive attitudes about life | 39.57 (3.91) | 57.78 (3.10)*** | 61.17 (3.51)*** |
| Negative attitudes about life | 3.82 (0.99) | 5.08 (1.54) | 3.18 (0.96) |
| Positive attitudes about self | 35.16 (3.80) | 50.70 (3.46)*** | 54.78 (3.37)*** |
| Negative attitudes about self | 3.89 (0.86) | 4.80 (1.43) | 3.52 (1.16) |
| Positive mood changes | 36.85 (3.99) | 49.06 (3.45)*** | 55.32 (3.58)*** |
| Negative mood changes | 3.42 (1.18) | 5.42 (1.57) | 3.00 (1.18) |
| Altruistic/positive social effects | 35.60 (3.79) | 47.42 (3.49)*** | 51.11 (3.69)*** |
| Antisocial/negative social effects | 3.55 (1.11) | 3.73 (1.06) | 2.51 (0.90) |
| Positive behavior changes | 48.40 (4.66) | 59.60 (4.02)*** | 64.78 (4.03)*** |
| Negative behavior changes | 1.60 (1.27) | 3.60 (1.97) | 0.87 (0.61) |
| Increased spirituality | 37.07 (4.31) | 52.48 (3.88)*** | 57.43 (4.17)*** |
| Decreased spirituality | 1.68 (0.63) | 1.88 (0.68) | 1.27 (0.39) |
| How personally meaningful was the experience? (maximum score=8) | 4.62 (0.31) | 6.38 (0.20)*** | 6.65 (0.18)*** |
| Top 5 most meaningful of life, including single most (% of participants) | 24% | 62%*** | 67.4%*** |
| How spiritually significant was the experience? (maximum score=6) | 3.16 (0.24) | 4.46 (0.19)*** | 4.78 (0.17)*** |
| Top 5 most spiritually significant of life, including single most (% of participants) | 24% | 66%*** | 69.6%*** |
| Did the experience change your sense of well-being or life satisfaction? (maximum score=3) | 1.50 (0.19) | 2.20 (0.16)*** | 2.33 (0.14)*** |
| Increased well-being or life satisfaction moderately or very much (% of participants) | 52% | 86%*** | 82.6%*** |
Except where noted, numerical data show means (1 SEM) for persisting effects ratings 5 weeks after the low-dose session (n = 50), 5 weeks after the high-dose session (n = 50), and, again, retrospectively for the high-dose session 6 months after the second session (n = 46). There were no significant differences between ratings of the high dose at 5 weeks after the session vs. the 6-month follow-up. Asterisks indicate significant differences from ratings obtained 5 weeks after the low dose session (*p<0.05, **p<0.01, ***p<0.001, planned comparisons).