Skip to main content
. 2017 Mar 20;12:2143–2160. doi: 10.2147/IJN.S130566

Figure 7.

Figure 7

Effect of chronic administration of SCD on db/db mice treated for 12 weeks.

Notes: Effect of SC (42.1 μg/kg, SeNPs content is same to that of 20 nmol/kg SCD), SCD, Exendin-4, BAY55-9837 (20 nmol/kg, using the final concentration of peptides as the quantitative index) or the same volume of NS on (A) food intake, (B) body weight, (C) fasting glucose, (D) fasting insulin levels during 12-week treatment and (E) ITT of db/db mice after 12-week treatment. Data are the mean of eight independent experiments. Data presented as mean ± SEM. ##P<0.01, SCD or Exendin-4-treated mice vs BAY55-9837- or NS-treated mice.

Abbreviations: ITT, insulin tolerance test; NS, normal saline; SC, chitosan-modified selenium nanoparticles; SCD, DBAYL-conjugated, chitosan-modified selenium nanoparticles; SEM, standard error of the mean; SeNPs, selenium nanoparticles.