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Dependent variables and their constraints in the Box–Behnken design
| Dependent variables | Symbol | Constraints |
|---|---|---|
| Particle size | Y1 | Minimize |
| Particle size | Y1 | Minimize |
| PDI | Y2 | Minimize |
| Zeta potential | Y3 | >±20 |
| Drug loading | Y4 | Maximize |
Abbreviation: PDI, polydispersity index.
