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. 2017 Mar 20;12:2179–2188. doi: 10.2147/IJN.S127904

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© 2017 Du et al. This work is published and licensed by Dove Medical Press Limited

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Silica nanoparticles (SNPs)-induced gap junction intercellular communication (GJIC) inhibition in H9c2 cells. (A) SNPs-induced downregulation of GJIC in H9c2 cells. Lucifer yellow (LY, green) transferred to adjacent cells via open gap junctions. (B) The average distance of LY spread from the side of the scraped edge from six different sites in each sample was obtained and quantified. (C and D) Reduced expression of connexin 43 (Cx43) and P-Cx43 after SNPs treatment was detected using Western blot. Values represent the mean ± standard deviation (n=6). ^aP<0.05, vs control group; ^bP<0.05, vs 25 μg/mL group; ^cP<0.05, vs 50 μg/mL group.