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. 2016 Dec 9;10(2):91–101. doi: 10.1177/1756285616679369

Table 1.

Diagnostic criteria for CIDP based on European Federation of Neurological Societies (EFNS)/Peripheral Nerve Society (PNS) guidelines [Joint Task Force of the EFNS and the PNS, 2010].

Clinical Clinical involvement
time course
reflexes
Motor or sensory dysfunction in ⩾1 limb
⩾2 months
areflexia or hyporeflexia
Electrophysiological
EFNS
Definite
(always in ⩾2 nerves)
⩾1 of the following
• motor distal latency ⩾ 50% above ULN
• reduction of motor conduction velocity ⩾ 30% below LLN
• prolongation of F-wave latency in 2 nerves if these have distal negative peak CMAP amplitudes ⩾20% of LLN + ⩾1 other demyelinating parameter in ⩾1 nerve
• partial motor conduction block: ⩾50% amplitude reduction
• abnormal temporal dispersion (>30% duration increase)
• distal CMAP duration increase in ⩾1 nerve + ⩾1 other demyelinating parameter
Probable ⩾30% amplitude reduction of CMAP in ⩾2 nerves
Possible As in ‘definite’ but in only 1 nerve
Pathologic Sural nerve biopsy Demyelination and remyelination
supportive: subperineurial or endoneurial edema mononuclear cell infiltration ‘onion-bulb’ formation
Laboratory Cerebrospinal fluid Cell count <10/mm3
VDRL negative
supportive: elevated protein

CMAP, compound muscle action potential; LLN, lower limit of normal; ULN, upper limit of normal; VDRL, Venereal disease research laboratory.