Table 1.
Clinical | Clinical involvement time course reflexes |
Motor or sensory dysfunction in ⩾1 limb ⩾2 months areflexia or hyporeflexia |
Electrophysiological
EFNS |
Definite (always in ⩾2 nerves) |
⩾1 of the following • motor distal latency ⩾ 50% above ULN • reduction of motor conduction velocity ⩾ 30% below LLN • prolongation of F-wave latency in 2 nerves if these have distal negative peak CMAP amplitudes ⩾20% of LLN + ⩾1 other demyelinating parameter in ⩾1 nerve • partial motor conduction block: ⩾50% amplitude reduction • abnormal temporal dispersion (>30% duration increase) • distal CMAP duration increase in ⩾1 nerve + ⩾1 other demyelinating parameter |
Probable | ⩾30% amplitude reduction of CMAP in ⩾2 nerves | |
Possible | As in ‘definite’ but in only 1 nerve | |
Pathologic | Sural nerve biopsy | Demyelination and remyelination supportive: subperineurial or endoneurial edema mononuclear cell infiltration ‘onion-bulb’ formation |
Laboratory | Cerebrospinal fluid | Cell count <10/mm3
VDRL negative supportive: elevated protein |
CMAP, compound muscle action potential; LLN, lower limit of normal; ULN, upper limit of normal; VDRL, Venereal disease research laboratory.