Figure 1.
Serum ACE2 and DPP4 activities according to eGFR groups. (a) ACE2 serum activity was inversely correlated with eGFR. Patients with well-preserved eGFR (eGFR groups 1 and 2; >45 mL/min/1.73 m2) had lower ACE2 activities than groups 3–5 (P < 0.00016). (b) DPP4 activity according to eGFR groups. Significantly higher DPP4 serum activities were observed in patients with eGFR < 15 mL/min/1.73 m2 compared to serum activity of patients with eGFR ≥ 15 mL/min/1.73 m2 (p = 3.73 × 10−5).
ACE2: angiotensin I-converting enzyme 2; DPP4: dipeptidyl-peptidase 4; eGFR: estimated glomerular filtration rate