Table 4. Gene-to-gene interactions of eNOS and Cav-1 polymorphisms in association with LAA stroke.
| Genotypes | Cases (%) | Controls (%) | aOR (95% CI) a | |
|---|---|---|---|---|
| eNOS G894T | Cav-1 G14713A | |||
| GG | GG | 95 (41.5) | 129 (53.1) | 1.00 (Ref) b |
| GG | GA/AA | 56 (24.4) | 56 (23.1) | 1.47 (0.96–2.25) |
| GT/TT | GG | 43 (18.8) | 45 (18.5) | |
| GT/TT | GA/AA | 35 (15.3) | 13 (5.3) | 4.12 (1.88–9.03)*** |
| One additional risk-genotype | 1.77 (1.28–2.44); Pinteraction < 0.001 | |||
| eNOS G894T | Cav-1 T29107A | |||
| GG | TT | 91 (39.7) | 126 (51.8) | 1.00 (Ref) |
| GG | TA/AA | 60 (26.2) | 59 (24.3) | 1.42 (0.93–2.19) |
| GT/TT | TT | 37 (16.2) | 41 (16.9) | |
| GT/TT | TA/AA | 41 (17.9) | 17 (7.0) | 3.08 (1.52–6.25)** |
| One additional risk-genotype | 1.63 (1.19–2.22) Pinteraction = 0.002 | |||
| eNOS 894GG | ||||
| Cav-1 G14713A | Cav-1 T29107A | |||
| GG | TT | 78 (51.6) | 110 (59.5) | 1.00 (Ref) |
| GG | TA/AA | 30 (19.9) | 35 (18.9) | 1.20 (0.69–2.13) |
| GA/AA | TT | |||
| GA/AA | TA/AA | 43 (28.5) | 40 (21.6) | 1.53 (0.91–2.58) |
| One additional risk-genotype | 1.23 (0.96–1.59) P-trend = 0.108 | |||
| eNOS 894GT/TT | ||||
| Cav-1 G14713A | Cav-1 T29107A | |||
| GG | TT | 29 (37.2) | 36 (62.1) | 1.00 (Ref) |
| GG | TA/AA | 22 (28.2) | 14 (24.1) | 1.95 (0.85–4.46) |
| GA/AA | TT | |||
| GA/AA | TA/AA | 27 (34.6) | 8 (13.8) | 4.20 (1.66–10.63)** |
| One additional risk-genotype | 2.03 (1.30–3.18) P-trend = 0.002 | |||
a aORs and 95% CIs were calculated in multivariate logistic regression model considering factors of age of onset and sex.
b Ref, reference group.
**, P < 0.01 and
***, P < 0.001