Table 5. Risk elevation of an LAA stroke in individuals with the eNOS 894Asp variant genotype in combination with Cav-1 polymorphisms stratified by hypercholesterolemia, alcoholism, or heavy cigarette smoking.
| No. of Cav-1 risk genotypes | Hypercholesterolemia | Alcoholism | Heavy cigarette smoking | ||||||
|---|---|---|---|---|---|---|---|---|---|
| aOR (95% CI) a | P-value | aOR (95% CI) | P-value | aOR (95% CI) | P-value | ||||
| 0 | Null | 1.00 (Ref) b | Null | 1.00 (Ref) | Null | 1.00 (Ref) | |||
| 0 | Yes | 2.94 (0.96–8.97) | 0.057 | Yes | 1.05 (0.28–3.88) | 0.960 | Yes | 1.32 (0.39–4.48) | 0.658 |
| 1 | Null | 1.56 (0.49–4.93) | 0.447 | Null | 1.77 (0.71–4.41) | 0.222 | Null | 1.45 (0.52–4.48) | 0.475 |
| 1 | Yes | 5.36 (1.57–18.28) | 0.007 | Yes | 3.10 (0.55–17.55) | 0.201 | Yes | 3.63 (1.02–13.03) | 0.048 |
| 2 | Null | 4.30 (1.34–13.78) | 0.014 | Null | 3.97 (1.37–11.51) | 0.011 | Null | 3.07 (1.01–9.33) | 0.049 |
| 2 | Yes | 12.26 (2.39–62.95) | 0.003 | Yes | 4.97 (0.96–25.7) | 0.056 | Yes | 8.61 (1.74–42.50) | 0.008 |
| Additive effect on IS risk elevation | 1.51 (1.21–1.87) | 1.41 (1.14–1.75) | 0.002 | 1.43 (1.16–1.77) | 0.001 | ||||
a aORs and 95% CIs were estimated in multivariate logistic regression model after adjusting for the age of onset and sex.
b Ref, reference group; the risks were estimated using the subjects harboring no high-risk genotypes (Cav-1 14713GG and 29107TT genotype) as the reference.