Table 1. Patients with EBV-positive T/NK-LPDs and analyses of EBV-infected cells in their peripheral blood.
| Case | Gender | Age | Infected cell | Clinical findings | EBV DNA load of each fraction of PBMCs (copies/μgDNA) | The marker used for the isolation of the infected cells | The clonality of the infected cells | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| total | CD4 | CD8 | CD56 | CD14 | CD19 | |||||||
| CD4-1 | F | 25 | CD4 | HMB | 7.0 x 104 | 2.2 x 105 | N.D. | N.D. | N.D. | N.D. | CD4 | monoclonal |
| CD4-2 | F | 62 | CD4 | sCAEBV | 3.2 x 104 | 4.6 x 105 | N.D. | N.D. | N.D. | N.D. | CD4 | monoclonal |
| CD8-1 | F | 21 | CD8 | sCAEBV | 1.8 x 103 | N.D. | 6.0 x 102 | N.D. | N.D. | N.D. | CD8 | monoclonal |
| CD8-2 | F | 64 | CD8 | sCAEBV | 2.6 x 105 | N.D. | 1.2 x 106 | N.D. | N.D. | 4.6 x 105 | CD8 | monoclonal |
| CD8-3 | F | 64 | CD8 | sCAEBV | 4.7 x 104 | N.D. | 1.7 x 104 | N.D. | N.D. | 7.6 x 103 | CD8 | monoclonal |
| CD56-1 | F | 18 | CD56 | HMB | 5.2 x 104 | N.D. | N.D. | 1.1 x 106 | N.D. | 7.5 x 104 | CD56 | monoclonal |
| CD56-2 | F | 48 | CD56 | sCAEBV | 8.6 x 104 | N.D. | N.D. | 1.0 x 105 | N.D. | N.D. | CD56 | monoclonal |
| CD56-3 | M | 24 | CD56 | sCAEBV | 2.9 x 103 | N.D. | N.D. | 2.1x 104 | N.D. | N.D. | CD56 | monoclonal |
M: Male, F: Female; EBV: Epstein-Barr virus, PBMCs: peripheral blood mononuclear cells; HMB: hypersensitivity to mosquito bites, sCAEBV: systemic chronic active Epstein-Barr virus infection; N.D.: not detected.