Table 2.

In vitro activities among different quinolones

Organism	No of strains	Antibacterial agents	MIC range	MIC50	MIC90	Ref
Staphylococcus aureus FQ-S	70	LVX	0.06–0.5	0.25	0.5	25
	88	LVX	0.06–1	0.12	0.25	26
	70	MXL	0.015–0.5	0.06	0.1	25
	70	DLX	0.002–0.008	0.004	0.008	25
	88	DLX	≤0.001–0.06	0.002	0.008	26
S. aureus FQ-R	71	LVX	4–64	16	32	25
	100	LVX	2–32	4	8	26
	71	MXL	0.25–16	4	8	25
	71	DLX	0.015–1	0.25	1	25
	100	DLX	0.015–2	0.006	0.12	26
Coagulase-negative staphylococci	19	LVX	0.06–>32	0.12	>32	26
	19	DLX	0.001–2	0.004	1	26
S. pneumoniae FQ-S	69	LVX	0.5–2	1	1	25
	69	MXL	0.06–0.25	0.12	0.12	25
	69	DLX	0.004–0.015	0.008	0.015	25
S. pneumoniae FQ-R	33	LVX	2–32	16	32	25
	33	MXL	0.25–8	2	4	25
	33	DLX	0.015–0.5	0.12	0.5	25
Neisseria gonorrhoeae	100	CPX	≤0.015–16	≤0.015	8	27
	100	DLX	≤0.0005–0.06	0.001	0.06	27
Enterococcus faecium FQ-R	28	LVX	8–>128	32	64	25
	28	MXL	1–32	16	16	25
	28	DLX	0.25–16	4	8	25
Escherichia coli FQ-R	27	CPX	4–>128	128	>128	25
	27	DLX	1–16	4	8	25
Klebsiella pneumoniae FQ-R	22	CPX	4–64	32	64	25
	22	DLX	1–4	2	4	25
Bacteroides fragilis	16	LVX	1–2	2	2	23
	16	DLX	0.03–0.12	0.06	0.12	23
Pseudomonas aeruginosa FQ-R	21	CPX	2–128	32	128	25
	21	DLX	1–128	32	128	25

Abbreviations: CPX, ciprofloxacin; DLX, delafloxacin; FQ, fluoroquinolone; LVX, levofloxacin; MXL, moxifloxacin.