Table 2.
Relative mRNA level of expression of apoptosis and cell cycle-related genes in MCF-7 cells after treatment with 10 µM Artonin E for 24 h
| No | Gene | Relative expression (% Log [fold change]) |
|---|---|---|
| 1 | Bcl-2 | −13.8±0.09 |
| 2 | Cyc | 19.0a±0.01 |
| 3 | Bax | 15.5a±0.04 |
| 4 | MAPK 8 | −21.1b±0.06 |
| 5 | Apaf1 | 6.4±0.04 |
| 6 | Akt1 | −6.8±0.05 |
| 7 | Caspase 7 | 51.8a±0.03 |
| 8 | Caspase 8 | 8.8±0.01 |
| 9 | Caspase 9 | 17.3a±0.02 |
| 10 | Cyclin D | −23.7b±0.19 |
| 11 | Cyclin E | −15.3±0.09 |
| 12 | p21 | 23.7a±0.05 |
Notes: Values are expressed as mean ± standard deviation of three replicates at P<0.05.
Significantly upregulated,
Significantly downregulated.