Table 3.

Cancer screening recommendations for patients with LFS

	NCCN	NICE	eviQ
	USA	UK	Australia
Breast	• Clinical exam every 6–12 months, starting at age 20–25 years • Age 20–29 years, annual MRI with contrast or mammogram if MRI unavailable • Age 30–75 years, annual mammogram and breast MRI with contrast • Age >75 years, management on individual basis • Discuss risk-reducing mastectomy	• 20–49 years, annual breast MRI • 50–70 years, consider annual breast MRI	• 20–50 years, annual breast MRI. Mammogram/ultrasound should be considered only if unable to access MRI
Colon	• Colonoscopy every 2–5 years starting at age 25 years or 5 years before earliest colon cancer in the family		• Colonoscopy every 2–5 years from age 25 years or younger if there is a family history of bowel cancer
Other cancers	• Address limitations of screening for many cancers associated with LFS • Annual comprehensive H&P (including neurologic examination) • Annual dermatologic examination • Annual whole-body MRI (or equivalent), preferably in the context of a clinical trial • Brain MRI		• Annual H&P • Further investigations if clinically indicated

Abbreviations: eviQ, eviQ cancer treatments online; H&P, history and physical exam; LFS, Li–Fraumeni syndrome; MRI, magnetic resonance imaging; NCCN, National Comprehensive Cancer Network; NICE, National Institute for Health and Care Excellence.