Fig 4. Therapeutic oral administration of BBG9-1 suppresses RV replication in the intestine of RV-infected mice.

Oral administration of BBG9-1 and inoculation of RV were performed as described in the legend of Fig 2. Virus titers (PFU/mg) in mixtures of cecum and colonic contents were measured by plaque assays 2–5 days after infection. Data are shown as medians and interquartile range (n = 5 or 6 pups for each group). **p < 0.01 by the Mann-Whitney U test.