Fig 5. Three-stage model profile likelihoods.

Profiles of the relative negative log-likelihood (NLL) of the three-stage clonal expansion model as each of parameter combinations p₃, q₃, νX, and μ₁/α are varied while the remaining parameters are fit. The gray dotted line gives the α = 0.01 threshold for simultaneous confidence intervals based on the relative negative log-likelihood. Parameter combinations p₃ and p₄ are identifiable, while νX and μ₁/α are practically unidentifiable.