Fig 7. Profile likelihood for the reparameterized combination of the three-stage model.

Profile of the relative negative log-likelihood (NLL) as the parameter $r_3=\sqrt{\nu X{\mu }_1/\alpha }$ is varied while the remaining parameters are fit in the three-stage clonal expansion model. The gray dotted line gives the α = 0.01 threshold for simultaneous confidence intervals based on the relative negative log-likelihood. Parameter combination r₃ is identifiable.