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. 2017 Mar 13;13(3):e1005431. doi: 10.1371/journal.pcbi.1005431

Fig 10. Profile likelihood for the reparameterized combination of the four-stage model.

Fig 10

Profile of the relative negative log-likelihood (NLL) as the parameter r4 = (νXμ1μ2/α)1/3 is varied while the remaining parameters are fit in the four stage clonal expansion model. The gray dotted line gives the α = 0.01 threshold for simultaneous confidence intervals based on the relative negative log-likelihood. Parameter combination r4 is identifiable.