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. 2017 Mar 27;12(3):e0174416. doi: 10.1371/journal.pone.0174416

Fig 2. Endogenous 24S-HC exacerbates OGD-induced, NMDAR-dependent cell death.

Fig 2

(A) Survival rate was compared between WT and KO cells with/without OGD challenges, and with OGD/APV co-treatment. Following OGD treatment, KO cells had significantly higher survival rate compared to WT cells (n = 5 cultures for WT and 5 cultures for KO; one-way ANOVA with Bonferroni’s post hoc test, *P < 0.05). (B) 24S-HC concentration (ng/ml) was measured in MEM and the original conditioned medium (CM) immediately following OGD insult and one hour after, respectively. (C) 24S-HC levels measured both immediately following OGD insult and one hour after insult, as shown in (B), were normalized to 24S-HC measured in the sibling untreated control cultures shown in (B) (n = 5 for control cultures and 6 for OGD cultures; P > 0.2).