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. 2017 Mar 27;12(3):e0174416. doi: 10.1371/journal.pone.0174416

Fig 4. 25-HC alone is neuroprotective against OGD-induced cell death, independent of NMDARs.

Fig 4

(A) Survival rates from cultures treated with APV before or after OGD insult were normalized to the survival rate of cultures treated with OGD alone. APV (50 μM) administered before OGD insult had significantly larger neuroprotective effects on the survival rate compared to APV administered after OGD insult (n = 7 cultures for APV-before; n = 15 cultures for APV-after; *P < 0.05). (B) Survival rates from cultures treated with 25-HC before or after OGD insult were normalized to the survival rate of cultures treated with OGD alone. Administration of 25-HC (10 μM) before and after OGD insult had indistinguishable rescuing effects on survival (n = 15 cultures for each group; P > 0.2).