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. 2017 Mar 27;12(3):e0174416. doi: 10.1371/journal.pone.0174416

Fig 5. 25-HC alone does not protect against NMDA-induced cell death, but it alleviates 24S-HC exacerbated toxicity.

Fig 5

(A) Application of NMDA at 8 μM and 20 μM significantly reduced cell survival, which was not inhibited when cells were co-treated with 10 μM 25-HC (n = 13 cultures for each group, one-way repeated measures ANOVA with Bonferroni’s post hoc test, ***P < 0.001). (B) Application of 24S-HC significantly exacerbated 8 μM NMDA-induced cell death. The exacerbation was inhibited by 10 μM 25-HC (n = 6 cultures for each group, one-way repeated measures ANOVA with Bonferroni’s post hoc test, *P < 0.05).