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. 2017 Mar 23;10(3):346–356. doi: 10.1016/j.tranon.2017.01.014

Figure 3.

Figure 3

ROR expression relationship in tumor and stroma. Each panel represents number of tumor ROR expression scores for each stroma score (x-axis, ROR S_0, ROR S_1, ROR S_2 and ROR S_3). Tumor ROR scores are represented by shading and distribution listed underneath. Each graph is paired with a representative image of the overall pattern of expression for that subtype. (A) ROR1 tumor and stroma expression in clear cell OC showed overall low stroma intensity but high tumor intensity. (B) ROR2 expression was overall low in both tumor and stroma in clear cell OC. (C) ROR1 expression in endometrioid OC was overall strong in tumor cells and weak in stroma. (D) ROR2 expression in endometrioid OC was very strong in tumor cells and absent in stroma. (E) ROR1 expression in mucinous OC was high in tumor and low in stroma. (F) ROR2 expression in mucinous OC was overall weak in both tumor and stroma. (G) ROR1 expression in serous tumor increased as stroma expression increased, but overall expression was mid to low. (H) ROR2 expression in serous OC tumor decreased as stroma expression increased. All cases with a stromal score of 3 exhibited absent tumor expression.