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. 2017 Mar 24;23:160–170.

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Copyright © 2017 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed.

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Ball-and-sockets (BSs) in 8-week-old lenses. A: BS (arrowheads) in 8-week-old wild-type (WT) lenses resemble those at 3 weeks. B: Connexin 50 (Cx50) knockout (KO) lenses have balloon-like structures (asterisks) that resemble BSs that are pinched at their base. C: Knock-in (Ki) lenses have BSs (arrowheads) and balloon-like structures (asterisks). D-F: Cx46 is enriched on BSs (arrowheads) but absent or nearly absent from balloon-like structures (asterisks). Images taken approximately 100 μm from the sample edge. Scale bar: 5 μm. G: Schematic of Cx46 (green) and F-actin (magenta) distributions relative to BSs and balloons in 8-week-old WT, Cx50 KO, and Ki lenses.