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. 2017 Mar 21;10:1735–1742. doi: 10.2147/OTT.S132806

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© 2017 Li et al. This work is published and licensed by Dove Medical Press Limited

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EphB4 and EFNB2 are highly expressed in ER-negative breast cancer and their overexpression strongly correlates in HER2-positive subtype.

Notes: (A, B) Amplification of EphB4 and EFNB2 gene is recurrent in breast carcinoma based on cBioPortal database. (C, D, G, H, K, L) The expression levels of EphB4 and EFNB2 tightly correlate in ER-negative breast cancers in the three independent cohorts. P-values were calculated with one-way ANOVA. (E, I, M) EphB4 expression correlates with EFNB2 in the three independent cohorts, especially (F, J, N) in the HER2-positive subtype. The linear regression Pearson’s correlation coefficient (R) and its P-value are indicated. *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001.

Abbreviations: ER, estrogen receptor; ANOVA, analysis of variance.