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. 2017 Mar 21;10:1711–1723. doi: 10.2147/OTT.S132120

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© 2017 Ye et al. This work is published and licensed by Dove Medical Press Limited

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The alteration of IRAK1 and its interaction in altered neighboring genes in 440 HCC cases from the cBioPortal database.

Notes: (A) IRAK1 alteration. In this cohort, 29% (126/440) of HCC cases exhibited IRAK1 alteration, including 85 cases of mRNA upregulation, 35 cases of mRNA downregulation, eight cases of amplification, three cases of missense mutation, two cases of truncating mutation and one case of deep deletion. Among them, eight cases possessed a mixed type of alteration. (B) Network of IRAK1 and altered neighboring genes. The network reflected easily identified interactions between IRAK1 and several genes, including MAP3K7, MAP2K4, NFKB1, AKT1 and ERC1.

Abbreviation: HCC, hepatocellular carcinoma.