Table 3.
Expression of IRAK1 detected by RNA sequencing and clinicopathological parameters in HCC in TCGA
| Clinicopathological parameters | n | IRAK1 expression
|
||
|---|---|---|---|---|
| Mean ± SD | t | P-value | ||
| Tissue (unmatched) | <0.001 | |||
| Adjacent noncancerous liver | 50 | 10.3058±0.5212 | 14.649 | |
| HCC | 354 | 11.5503±0.7946 | ||
| Tissue (matched) | <0.001 | |||
| Adjacent noncancerous liver | 49 | 10.2921±0.5174 | 10.703 | |
| HCC | 49 | 11.6174±0.8979 | ||
| Age (years) | 0.497 | |||
| <60 | 163 | 11.5168±0.7733 | −0.680 | |
| ≥60 | 190 | 11.5746±0.8132 | ||
| Gender | 0.116 | |||
| Male | 241 | 11.5958±0.8123 | 1.575 | |
| Female | 113 | 11.4534±0.7499 | ||
| AJCC pathologic T | 0.043 | |||
| T1 | 174 | 11.4647±0.7677 | −2.029 | |
| T2–T4 | 177 | 11.6363±0.8153 | ||
| AJCC pathologic N | 0.225 | |||
| N0 | 241 | 11.5107±0.7965 | F=1.498* | |
| N1 | 3 | 11.1300±0.4606 | ||
| NX | 109 | 11.6453±0.7940 | ||
| AJCC pathologic M | 0.149 | |||
| M0 | 256 | 11.5036±0.7794 | F=1.912* | |
| M1 | 4 | 11.3702±0.6400 | ||
| MX | 94 | 11.6853±0.8317 | ||
| Pathologic stage | 0.135 | |||
| I–II | 245 | 11.4982±0.7800 | −1.499 | |
| III–IV | 83 | 11.6407±0.8398 | ||
| Vaso-invasion | 0.704 | |||
| − | 196 | 11.4945±0.7900 | −0.380 | |
| + | 105 | 11.5311±0.7961 | ||
Note:
*
One-way ANOVA was performed.
Abbreviations: HCC, hepatocellular carcinoma; TCGA, the cancer genome atlas; AJCC, American Joint Committee on Cancer; ANOVA, analysis of variance; SD, standard deviation.