Table 2.
Pairwise Contrasts of Mean Scores Across All Parent Target Problem Panel Ratings and Parent-Rated Aberrant Behavior Checklist Hyperactivity Subscale After 1 Week on Each Active Dose Versus 1 Week on Placebo in the 4-Week Crossover Trial
PTP ratinga | ABC hyperactivity | p | Effect sizeb | |||
---|---|---|---|---|---|---|
Dose | Mean (SE) | Mean (SE)c | PTP | ABC | PTP | ABC |
Placebo (n = 59) | 4.37 (0.13) | 25.97 (1.43) | ||||
Low (n = 60) | 4.29 (0.14) | 23.35 (1.51) | 0.63 | 0.14 | 0.09 | 0.26 |
Medium (n = 56)d | 4.12 (0.13) | 21.22 (1.41) | 0.11 | <0.01 | 0.27 | 0.46 |
High (n = 43)e | 3.99 (0.16) | 21.44 (1.49) | 0.04 | 0.01 | 0.40 | 0.44 |
Means are averaged over two PTPs, unless a subject had only one PTP.
Effect sizes calculated by subtracting model-based means and dividing by pooled SD for placebo; Placebo pooled SD for PTP = 0.94; Placebo pooled SD for ABC = 10.27.
ABC Hyperactivity subscale scores are not exactly as reported in RUPP Autism Network (2005) because of slight differences in sample size.
Medium dose scores for subjects randomized to receive medium dose twice were averaged.
Change in sample size because of missing data and modifications in random assignment to dose (see text).
ABC, Aberrant Behavior Checklist; PTPs, parent target problems; SE, standard error.