Table 3.
Pairwise Contrasts of Scores on Attention-Deficit/Hyperactivity Disorder-Related Parent Target Problem Panel Ratings and Parent-Rated Aberrant Behavior Checklist Hyperactivity Subscale After 1 Week on Each Active Dose Versus 1 Week on Placebo in the 4-Week Crossover Trial
| PTP rating | ABC hyperactivity | p | ESa | |||
|---|---|---|---|---|---|---|
| Dose | Meanb(SE) | Mean (SE) | PTP | ABC-H | PTP | ABC-H |
| Placebo (n = 57) | 4.36 (0.15) | 25.37 (1.47) | ||||
| Low (n = 58) | 4.28 (0.15) | 23.38 (1.58) | 0.63 | 0.26 | 0.08 | 0.20 |
| Medium (n = 54)c | 4.11 (0.14) | 21.31 (1.46) | 0.12 | 0.01 | 0.24 | 0.40 |
| High (n = 41)d | 3.92 (0.18) | 20.73 (1.48) | 0.02 | 0.01 | 0.42 | 0.46 |
Effect sizes calculated by subtracting model-based means and dividing by pooled SD for placebo; Placebo pooled SD for PTP = 1.06; Placebo pooled SD for ABC = 10.07.
Means are averaged over two ADHD-related PTPs, unless a subject had only one PTP.
Medium dose scores for subjects randomized to receive medium dose twice were averaged.
Change in sample size because of missing data and modifications in random assignment to dose (see text).
ABC, Aberrant Behavior Checklist; ABC-H, Aberrant Behavior Checklist Hyperactivity; ADHD, attention-deficit/hyperactivity disorder; PTPs, parent target problems; SE, standard error.