Table 1. Experimental Groups.

A. When measuring the COC-induced LMA and the CART peptide effect in this group, only a CART peptide dose of 2.5 μg/side (and saline as a control) was used, but the COC dose varied (0, 10, 15 mg/kg). In addition, the gender was also varied. The experimental details are given in the text. The number of rats used are shown above.

B. When measuring the COC-induced LMA and the CART peptide effect in this group, the CART peptide dose varied (0, 1.0, 2.5 μg/side) while the COC dose was held constant (10 mg/kg). The sex (males) is held constant. Note that the CART peptide dose (2.5 μg/side) is the same as in experiment A above for males. The experimental details are given in the text. The number of rats used are shown above.

C. Similar to A above, but for a different PS (AMPH). When measuring the AMPH-induced LMA and the CART peptide effect in this group, only a CART peptide dose of 2.5 μg/side (and saline as a control) was used, but the AMPH dose varied (0, 0.3 and 2.0 mg/kg). The sex (males) is held constant. The experimental details are given in the text. The number of rats used are shown above.

A.
Sex	Intra-NAc CART peptide dose (μg/side)	Cocaine dose (mg/kg i.p.)
		0	10	15
Males	0, 2.5	(n = 6)	(n = 13)	(n = 10)
Females	0, 2.5	(n = 11)	(n = 15)	(n = 11)

B.
Intra-NAc CART peptide dose (μg/side)	Cocaine (10 mg/kg i.p.)
0, 1.0	(n = 9)
0, 2.5	(n = 13)

C.
Intra-NAc CART peptide dose (μg/side)	Amphetamine dose (mg/kg i.p.)
	0	0.3	2.0
0, 2.5	(n = 6)	(n = 6)	(n = 6)