Table 1.
Baseline characteristics and neonatal respiratory outcomes of infants discharged alive by treatment group (late surfactant versus control)
| Follow-up cohort (n=450) | Late surfactant (n=217) | Control (n=233) | P value | ||
|---|---|---|---|---|---|
| GA (weeks) | 25.3±1.2 | 25.3±1.2 | 25.3±1.2 | 0.90 | |
| < 26 0/7 weeks’ | 310 (68.9) | 148 (68.2) | 162 (69.5) | 0.76 | |
| Birth weight (g) | 713±164 | 715±174 | 711±154 | 0.81 | |
| Intrauterine growth restriction | 73 (16.2) | 40 (18.4) | 33 (14.2) | 0.22 | |
| Antenatal steroids | 388 (86.2) | 184 (84.8) | 204 (87.6) | 0.11 | |
| Male sex | 248 (55.1) | 124 (57.1) | 124 (53.2) | 0.40 | |
| Multiple gestation | 139 (30.9) | 56 (25.8) | 83 (35.6) | 0.02 | |
| Multiple siblings enrolled | 102 (22.7) | 41 (18.9) | 61 (26.2) | 0.07 | |
| Maternal characteristics | |||||
| Race/ethnicity | 0.47 | ||||
| White, non-Hispanic | 220 (48.9) | 101 (46.5) | 119 (51.1) | ||
| African American | 159 (35.3) | 82 (37.8) | 77 (33.0) | ||
| Hispanic | 50 (11.1) | 21 (9.7) | 29 (12.4) | ||
| Asian | 13 (2.9) | 5 (2.1) | 8 (3.7) | ||
| Other | 8 (1.8) | 5 (2.3) | 3 (1.3) | ||
| Age (y) | 28.8±6.4 | 27.8±6.1 | 29.8±6.6 | 0.0007 | |
| Education | 0.06 | ||||
| High school not complete | 56 (12.4) | 23 (10.6) | 33 (14.2) | ||
| High school graduate or some college | 227 (50.4) | 123 (56.7) | 104 (44.6) | ||
| College graduate ± graduate school | 166 (36.9) | 71 (32.7) | 95 (40.8) | ||
| Unknown | 1 (0.2) | 0 | 1 (0.4) | ||
| Neonatal respiratory outcomes | |||||
| BPD at 36 weeks’ PMA | 291 (64.7) | 140 (64.5) | 151 (64.8) | 0.95 | |
| BPD at 40 weeks’ PMA | 165 (36.7) | 71 (32.7) | 94 (40.3) | 0.09 | |
| Duration of mechanical ventilation (d) | 41.9±30.4 | 42.3±30.6 | 41.4±30.3 | 0.77 | |
Data are mean ± standard deviation or n (%)
P value by t-test or chi-square
Intrauterine growth restriction ≤ 10th percentile for gestational age per fetal growth curves derived from Fenton and Kim, 2013 (38).