. Author manuscript; available in PMC: 2018 Apr 1.

Published in final edited form as: Gastroenterology. 2017 Jan 6;152(5):1042–1054.e1. doi: 10.1053/j.gastro.2016.12.039

Appendix Table 5.

Subgroup analysis for observed differences in the prevalence of PI-IBS within 12m and >12m of infectious exposure, based on the pathogen-type

Subgroups	Events/Total exposed (No. of studies)	Prevalence of PI-IBS (%)	95% CI	I²

Within 12m of exposure^*

Overall	911/15800 (35)	10.1	7.2–14.1	96%

Organism^†, ^‡
• Bacterial	656/10016 (21)	13.0	8.5–19.5	97%
• Viral	53/264 (2)	19.4	13.2–27.7	48%
• Protozoal	5/72 (1)	6.9	2.9–15.6	-

>12m after exposure

Overall	1466/12007 (15)	14.5	7.7–25.5	99

Organism^§
• Bacterial	691/8053 (7)	12.9	4.6–31.3	99
• Viral	26/1839 (3)	4.4	0.3–39.9	97
• Protozoal	712/1647 (3)	53.0	39.9–65.7	95

when data at multiple time points was reported in a study, hierarchical order of 12m, 6m and 3m rates was used for estimation

^†

excluded 9 studies which did not report specific exposure organism or was mixed etiology

^‡

p-value for difference between subgroups=0.06, suggesting that organism of exposure does not significantly influence observed prevalence of PI-IBS within 12m

^§

p-value for difference between subgroups=<0.001, suggesting that the infecting organism affects prevalence of PI-IBS >12m after exposure