Table 2.
Physiologic parameters of infant rhesus macaques at 20 (P20) or 40 (P40) days of age or before, during, and after control versus isoflurane anesthesia.
| Baseline (0 h) | 1 h | 2.5 h | 5 h | |
|---|---|---|---|---|
| Heart rate (min−1) | ||||
| P20 Control | 95 (93–95) | 95 (95–95) | 96 (95–99) | 96 (95–99) |
| P20 Isoflurane |
97 (96–98) | 97 (97–99) | 98 (97–99) | 99 (98–100) |
| P40 Control | 99 (97–100) | 99 (98–99) | 96 (95–99) | 98 (97–100) |
| P40 Isoflurane |
97 (97–99) | 98 (97–100) | 99 (99–100) | 100 (98–100) |
| MAP (mm Hg) | ||||
| P20 Control | 125 (102–147) | nc | 69 (68–105) | 99 (60–102) |
| P20 Isoflurane |
106 (103–108) | 42 (42–42) | 35 (29–41) | 48 (28–60) |
| P40 Control | 75 (75–75) | 62 (45–78) | 84 (65–98) | 71 (70–96) |
| P40 Isoflurane |
71 (45–89) | 38 (26–46) | 33 (26–36) | 36 (35–52) |
| SpO2 (%) | ||||
| P20 Control | 95 (93–95) | 95 (95–95) | 96 (95–99) | 96 (95–99) |
| P20 Isoflurane |
97 (96–98) | 97 (97–99) | 98 (97–99) | 99 (98–100) |
| P40 Control | 99 (97–100) | 99 (98–99) | 96 (95–99) | 98 (97–100) |
| P40 Isoflurane |
97 (97–99) | 98 (97–100) | 99 (99–100) | 100 (98–100) |
| Temperature (rectal, °C) | ||||
| P20 Control | 37.3 (36.7–37.9) |
nc | 38.3 (38.3–38.5) |
38.6 (38.4–38.7) |
| P20 Isoflurane |
37.3 (36.9–38.0) |
35.5 (35.0–37.0) |
37.6 (37.6–38.0) |
37.1 (36.0–38.4) |
| P40 Control | 37.1 (36.9–38.4) |
38.5 (38.1–38.8) |
38.7 (38.2–38.7) |
38.6 (37.4–38.7) |
| P40 Isoflurane |
37.2 (36.4–37.8) |
36.6 (36.3–38.4) |
37.4 (37.4–37.6) |
38.4 (38.2–38.8) |
| Glucose (mg/dL) | ||||
| P20 Control | 103 (97–183) | nc | 84 (63–97) | 80 (56–94) |
| P20 Isoflurane |
88 (77–94) | 98 (86–100) | 84 (64–184) | 77 (60–106) |
| P40 Control | 84 (74–89) | nc | 75 (73–76) | 67 (40–69) |
| P40 Isoflurane |
73 (69–100) | 91 (84–178) | 68 (66–122) | 68 (65–70) |
Data are presented as median (range: min-max);
nc = not collected; SpO2 = peripheral capillary oxygen saturation; MAP = mean arterial pressure (noninvasive).