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Two intersecting pathways that affect AIN in C. elegans. The grouping on the left of the figure (blue ellipses) represents the DAF-2 pathway which, when induced, is capable of inhibiting AIN. The genes on the right (red ellipses) are activated by ROS, leading to ER-stress, apoptosis and causing AIN. The mitochondrial/ROS isoflurane target is at the bottom in green. The pathways are expanded in the upper inserts.
