Table 2. Cox Model for CLAD with Time-Dependent Covariates.
| Univariable | Multivariable† | |||||
|---|---|---|---|---|---|---|
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|
|
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| HR | 95% CI | p-value | HR | 95% CI | p-value | |
|
|
|
|
|
|
|
|
| DAD < 6 months | 1.2 | 0.9 - 1.8 | 0.2545 | |||
| DAD ≥ 6 months | 4.9 | 2.8 - 8.4 | 0.0001 | 2.8 | 1.5 - 5.3 | 0.0020 |
| OP < 6 months | 1.2 | 0.8 - 1.7 | 0.4037 | |||
| OP ≥ 6 months | 3.3 | 2.1 - 5.1 | 0.0001 | 2.0 | 1.1 - 3.4 | 0.0177 |
| LB < 6 months | 1.2 | 0.9 - 1.6 | 0.1814 | |||
| LB ≥ 6 months | 1.8 | 1.3 - 2.4 | 0.0004 | 1.3 | 0.9 - 1.9 | 0.1839 |
| AR < 6 months | 1.4 | 1.0 - 1.8 | 0.0260 | 1.4 | 1.0 - 1.8 | 0.0319 |
| AR ≥ 6 months | 1.5 | 1.1 - 2.2 | 0.0137 | 1.2 | 0.8 - 1.8 | 0.3754 |
| Age > 70 | 1.3 | 0.8 - 2.1 | 0.2965 | |||
| Single lung | 1.3 | 1.0 - 1.7 | 0.0500 | |||
| Diagnosis: IPF | 0.9 | 0.7 - 1.2 | 0.5075 | |||
| Induction: ATG | 0.9 | 0.7 - 1.2 | 0.3705 | |||
Definition of abbreviations: CLAD = chronic lung allograft dysfunction; HR = hazards ratio; CI = confidience interval; ALI = acute lung injury; OP = organizing pneumonia; LB = lymphocytic bronchiolitis; AR = acute rejection; Single lung = single lung transplant; IPF = idiopathic pulmonary fibrosis; ATG - thymoglobulin;
†
Multivariable model includes only the variables listed.