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. 2017 Mar 6;174(8):628–640. doi: 10.1111/bph.13697

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© 2016 Genentech. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Depletion of CD20⁺ B cells following administration of anti‐CD22 or anti‐CD79b ADCs. Peripheral blood CD20⁺ B cells (panels A and B) or CD3⁺ T‐cells (panels C and D) in animals administered either anti‐CD22 (panels A and C) or anti‐CD79b (panels B and D) ADCs (n = 4); respective unconjugated antibodies (Ab) (n = 4) or vehicle (n = 4) over time are presented. Data presented are group mean absolute counts expressed as a percentage of baseline (% of BL) at each time point. Baseline was calculated as the average value obtained at two pre‐dose time points (shown). Error bars represent SEM. The arrow denotes administration of the test substances.