Figure 4.

Depletion of germinal centers in lymphoid tissues of cynomolgus monkeys administered anti‐CD22 ADC or anti‐CD79b ADC. (A) Representative H&E‐stained section of spleen from animals administered single i.v. doses of either vehicle (upper panel) or 6 mg·kg−1 anti‐CD22 ADC (lower panel) on Day 8 is presented. (B) Representative H&E‐stained section of spleen from animals administered four i.v. doses of vehicle (upper panel) or 5 mg·kg−1 anti‐CD79b ADC (lower panel) on Day 71 (7 days following fourth dose) is presented.