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. 2017 Mar 6;174(8):628–640. doi: 10.1111/bph.13697

Table 1.

Group mean (±SD) values of pharmacokinetic parameters for unconjugated or total antibodies (Ab) after a single i.v. administration of unconjugated anti‐CD22 antibody, unconjugated anti‐CD79b antibody or the respective ADCs at 3 mg·kg−1 to cynomolgus monkeys

PK parameters Anti‐CD22 Anti‐CD79b
Unconjugated Ab Total Ab Unconjugated Ab Total Ab
Cmax (μg·mL−1) 95.8 ± 3.00 80.6 ± 7.39 82.5 ± 4.93 98.3 ± 13.4
AUCinf (μg·day−1·mL−1) 606 ± 43.9 325 ± 48.7 289 ± 54.6 217 ± 36.1
Vss (mL·kg−1) 51.8 ± 1.59 80.0 ± 14.9 45.7 ± 3.36 43.1 ± 3.02
CL (mL·day−1·kg−1) 4.97 ± 0.352 9.39 ± 1.46 10.6 ± 1.86 14.2 ± 2.60