Table 1.
Group mean (±SD) values of pharmacokinetic parameters for unconjugated or total antibodies (Ab) after a single i.v. administration of unconjugated anti‐CD22 antibody, unconjugated anti‐CD79b antibody or the respective ADCs at 3 mg·kg−1 to cynomolgus monkeys
| PK parameters | Anti‐CD22 | Anti‐CD79b | ||
|---|---|---|---|---|
| Unconjugated Ab | Total Ab | Unconjugated Ab | Total Ab | |
| Cmax (μg·mL−1) | 95.8 ± 3.00 | 80.6 ± 7.39 | 82.5 ± 4.93 | 98.3 ± 13.4 |
| AUCinf (μg·day−1·mL−1) | 606 ± 43.9 | 325 ± 48.7 | 289 ± 54.6 | 217 ± 36.1 |
| Vss (mL·kg−1) | 51.8 ± 1.59 | 80.0 ± 14.9 | 45.7 ± 3.36 | 43.1 ± 3.02 |
| CL (mL·day−1·kg−1) | 4.97 ± 0.352 | 9.39 ± 1.46 | 10.6 ± 1.86 | 14.2 ± 2.60 |