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. 2017 Feb 27;174(8):718–733. doi: 10.1111/bph.13733

Figure 2.

Figure 2

(A) Recordings showing the time course of raloxifene‐induced relaxation in endothelium‐denuded aortic rings in control and in the presence of 100 μM L‐NAME and 3 μM ODQ. (B) Inhibitory effect of L‐NAME on raloxifene (1 μM)‐induced aortic relaxation and L‐arginine (L‐Arg, 0.5–1 mM) antagonized the effect of L‐NAME. (C) The inhibitory effect of ODQ on raloxifene (1 μM)‐induced aortic relaxation and lack of effect of 1 mM L‐arginine. (D) The maximal relaxant effect of raloxifene following different pharmacological manipulations. All experiments were performed on endothelium‐denuded rings. Statistical differences are indicated by *(P < 0.05) between vehicle control and raloxifene group, a (P < 0.05) between raloxifene and other treatment groups and b (P < 0.05) between L‐NAME and treatment groups. Results are mean ± SEM of 6–11 rings from different rats.